How Virginia Commonwealth University Uses Vibrent Health to Accelerate Data Collection and Novel Discoveries with Twins  - Vibrent

How Virginia Commonwealth University Uses Vibrent Health to Accelerate Data Collection and Novel Discoveries with Twins 


There is increasing evidence that some individuals suffer long term symptoms after recovering from COVID-19 infection, which has led to the term “long-haul COVID” (a term coined by patients who suffer these symptoms who have connected to each other on social media). 

Twin360 is a research effort by scientists at Virginia Commonwealth University (VCU) who want to get the full picture of the impact of COVID-19 on the health of twin families.  Twin360 analyzes long-term symptoms of COVID-19 that have been reported ranging across depression, exercise intolerance, weakness, and neurologic symptoms.

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Studying twins who had the virus, as well as those who did not, is a powerful way to expand our knowledge of COVID-19 and ideally improve our ability to support those impacted. The Twin360 project aims to provide a pathway for twins to take part in this innovative and important research, and the research team selected Vibrent’s Research Cloud and Participant Experience Manager products to power the study.

Twin360 Research Study by the Numbers


Twins enrolled in the Twin360 study


Of enrolled participants completed eConsent 


Completed at least one survey

Data Collection:  

  • eConsent 
  • Surveys 
  • Electronic health records (EHR) 
  • Data harmonization with other novel datasets 

Research Impact: 

Twin360 utilizes the Mid Atlantic Twin Registry (MATR), a registry of over 55,000 twins, to survey twins on COVID infection across twins and development of long-term symptoms. This will assist in understanding why some of those infected with the virus experience long-term or recurring symptoms or sometimes develop brand new symptoms months later.  

Twins are studied using the following methods: 

  • Cross sectional: Resolve genetic and environmental influences on outcome 
  • Longitudinal: Genetic and environmental influence on developmental change 
  • Discordant Monozygotic Twins: specific environmental influences 
  • Epigenetic or Gene Expression: Characterizing mechanisms of environmental influence 
  • Children of Twins: Social and genetic transmission of risk from parents to children 
  • Spouses of Twins: Analyzing the role of mate selection in populations 

About the Vibrent Health & VCU Collaboration:

VCU’s Twin360 Program uses Research Cloud to: 

  • Engage participants with email, SMS, and one-on-one engagement 
  • Access dashboards and reports for outreach performance 
  • View operational data insights about protocol compliance and other data 

Learn more about Research Cloud. 

VCU’s Twin360 Program uses Participant Experience Manager to: 

  • Enable genomic and biosample data collection 
  • Collect data from surveys 
  • Enable eConsent for access to electronic health records, wearables and other sources to create novel data sets 

Learn more about Participant Experience Manager.